Brainwave Discovery - delivering competitive advantage in CNS drug discovery

We offer our clients an effective means to get early in vivo CNS function data for more compounds and targets than is otherwise possible within limited R&D budgets. This allows you to follow many more innovative candidate molecules before committing to long-term, expensive animal and clinical trials. Our technologies also provide a new way to rapidly develop drugs with differential activity on allelic variants of established targets.

Brainwave Discovery delivers a highly customised service to pharmaceutical and biotechnology companies. Our scientists will work directly with yours to plan the work so you can be sure that the program and the data are tailored to your requirements.

Our solutions put human proteins – your potential drug development targets – in context in an insect brain ready for rapid pharmacological, behavioural or neurodegenerative testing. From this base, Brainwave Discovery will create neurophysiology and behaviour assays for molecules of your choice.

Benefits of Brainwave technologies:

• Unique in vivo CNS data for many more human targets when it is most needed – right at the start of drug development decision making
• Fast customised anti-neurodegeneration drug assays
• Fast screens for compounds affecting learning and memory

More than an assay - a molecular research lab in a fly brain

Brainwave Discovery provides specialist contract research services using human target molecules in a living insect brain. We specialise in the following areas:

• Learning/Cognition
• Neurodegeneration
• Novel target analysis

Learning and memory: Brainwave-Discovery technolgies are embedded in the very neurons that are the key to learning and memory. Changes in Brainwave activity provide a fast primary screen for compounds acting on human molecules involved in learning, with a secondary screen with our automatic learning assays allowing full confirmation of learning-specific effects.

Neurodegeneration: Drosophila has proved to be the best test-bed brain for human toxic mutant proteins. As well as providing customers with the most up-to-date custom humanized neurodegeneration assays, changes measured in our Brainwave system with neuron dysfunction allow very rapid drug screening without waiting weeks or months for an answer.

Novel target analysis: we offer our clients an effective means to get in vivo CNS data about human target protein function right at the start of the decision making process, and to include information about hundreds rather than a few targets in this process – because our procedures are so fast and cost effective.

More information on our solutions can be found here.