BrainWave Discovery specialises in the rapid development of in vivo brain assays for chemicals acting on human CNS targets selected by our clients. We use our expertise in "humanising" transgenic fruit flies (Drosophila) to deliver the desired human molecule to a specified subset of nerve cells in the insect brain.

To find out more about our services or our technology, please email us.

We offer our clients an effective means to get early in vivo CNS function data for more compounds and target, and multi-target complexes/pathways than is otherwise possible within limited R&D budgets. This allows you to follow many more innovative candidate molecules before committing to long-term, expensive animal and clinical trials. Our technologies also provide a new way to rapidly develop drugs with differential activity on allelic variants of established targets.

Brainwave Discovery delivers a highly customised service to pharmaceutical and biotechnology companies. Our scientists will work directly with yours to plan the work so you can be sure that the program and the data are tailored to your requirements. Contact us to arrange a comprehensive review of your requirements and solutions we can offer.

Our solutions put human proteins - your potential drug development targets - in context in an insect brain ready for rapid pharmacological, behavioural or neurodegenerative testing. From this base, Brainwave Discovery will create neurophysiology and behaviour assays for molecules of your choice.

Benefits of Brainwave technologies:

More than an assay - a molecular research lab in a fly brain

Brainwave Discovery provides specialist contract research services using human target molecules in a living insect brain. We specialise in the following areas:

Learning and memory: Brainwave-Discovery technolgies are embedded in the very neurons that are the key to learning and memory. Changes in Brainwave activity provide a fast primary screen for compounds acting on human molecules involved in learning, with a secondary screen with our automatic learning assays allowing full confirmation of learning-specific effects.

Neurodegeneration: Drosophila has proved to be the best test-bed brain for human toxic mutant proteins. As well as providing customers with the most up-to-date custom humanized neurodegeneration assays, changes measured in our Brainwave system with neuron dysfunction allow very rapid drug screening without waiting weeks or months for an answer.

Novel target analysis: we offer our clients an effective means to get in vivo CNS data about human target protein function right at the start of the decision making process, and to include information about hundreds rather than a few targets in this process - because our procedures are so fast and cost effective.